Basic Research
Basic research involves scientific exploration that can reveal fundamental mechanisms of biology, disease or behavior. Every stage of the translational research spectrum builds upon and informs basic research. NCATS scientists typically do not conduct basic research; however, insights gained from the Center’s studies along the translational spectrum can inform basic research.
Pre-Clinical Research
Pre-clinical research connects the basic science of disease with human medicine. During this stage, scientists develop model interventions to further understand the basis of a disease or disorder and find ways to treat it. Testing is carried out using cell or animal models of disease; samples of human or animal tissues; or computer-assisted simulations of drug, device or diagnostic interactions within living systems.
Clinical Research
Clinical research includes studies to better understand a disease in humans and relate this knowledge to findings in cell or animal models; testing and refinement of new technologies in people; testing of interventions for safety and effectiveness in those with or without disease; behavioral and observational studies; and outcomes and health services research. The goal of many clinical trials is to obtain data to support regulatory approval for an intervention.
Clinical Implementation
The clinical implementation stage of translation involves the adoption of interventions that have been demonstrated to be useful in a research environment into routine clinical care for the general population. This stage also includes implementation research to evaluate the results of clinical trials and to identify new clinical questions and gaps in care.
Public Health
In this stage of translation, researchers study health outcomes at the population level to determine the effects of diseases and efforts to prevent, diagnose and treat them. Findings help guide scientists working to assess the effects of current interventions and to develop new ones.
Back to top

Front

  • Oct
    23
    Wed, 10/23/2019 - 12:00 to 14:00

    Subomi Akindoju of the Patient-Centered Outcomes Research Institute (PCORI) visits GW for part one of a four-part series, Developing a Patient-Centered Approach to Research in Adult Cognitive Health and Dementia. A light lunch will be provided. Please RSVP. 

  • Oct
    28
    Mon, 10/28/2019 - 09:00 to 10:00

    Join us for October's RCR Series discussion led by Drs. Naomi Luban and Pam Hinds. Come contribute to a lively conversation about what constitutes research misconduct and how researchers can avoid research misconduct in a field that relies on emerging technologies.

  • Oct
    28
    Mon, 10/28/2019 - 13:00 to 14:00
    The Neuroscience Trainee-Sponsored Seminar Series hosts Anca Pasca, MD of Standford University. 
  • Oct
    29
    Tue, 10/29/2019 - 14:30 to 15:30


    ResearchMatch is an NIH-funded, national registry that brings together researchers and 140,000+ volunteers who are interested in learning more about research studies. This novel platform facilitates research participant recruitment, espcially involving surveys, rare disease, and healthy volunteers.

  • Nov
    8
    Fri, 11/08/2019 - 08:30 to 17:00


    You are invited to the 2nd Annual Children's National-NIAID Symposium, a partnership framed & supported through the CTSI-CN. This year, the event will highlight additional research collaborations between Children's National and other institutes within NIH, and also focus on genomics and care of children with immunologic diseases. UPDATE: The draft agenda is now available. 

  • Nov
    12
    Tue, 11/12/2019 - 10:30 to 12:30


    The Clinical and Translational Science Institute at Children's National (CTSI-CN) is pleased to continue to offer Research Electronic Data Capture (REDCap) training to the Children's National and GW research communities. Would your study or research benefit from web-based data entry? REDCap might be for you!

  • Nov
    12
    Tue, 11/12/2019 - 16:00 to 17:00

    Join us for a presentation from Lisa Adkins, JD, RN, CHC, and Cathy Pearcy on the topic of Conflict of Interest in Research. Questions that will be addressed include: What is the difference between actual and potential or perceived conflicts of interest? Who decides if I have a conflict of interest? If I have a conflict of interest, can I still take part in the activity? What do I do if I think a policy is being violated?

  • Nov
    13
    Wed, 11/13/2019 - 13:30 to 15:30


    The Clinical and Translational Science Institute at Children's National (CTSI-CN) is pleased to continue to offer Research Electronic Data Capture (REDCap) training to the Children's National and GW research communities. Would your study or research benefit from web-based data entry? REDCap might be for you!

  • Nov
    19
    Tue, 11/19/2019 - 12:30 to 13:30

    Join the Conway Chair Conversation the 3rd Tuesday of every month. A themed lunch will be served. WebEx available. CNE provided.

  • Nov
    25
    Mon, 11/25/2019 - 13:00 to 14:00
    The Neuroscience Trainee-Sponsored Seminar Series hosts Cristina Alberini, PhD of New York University. 
  • Dec
    4
    Wed, 12/04/2019 - 10:00 to 12:00


    The Clinical and Translational Science Institute at Children's National (CTSI-CN) is pleased to continue to offer Research Electronic Data Capture (REDCap) training to the Children's National and GW research communities. Would your study or research benefit from web-based data entry? REDCap might be for you!

  • Dec
    5
    Thu, 12/05/2019 - 10:00 to 12:00


    The Clinical and Translational Science Institute at Children's National (CTSI-CN) is pleased to continue to offer Research Electronic Data Capture (REDCap) training to the Children's National and GW research communities. Would your study or research benefit from web-based data entry? REDCap might be for you!

  • Dec
    17
    Tue, 12/17/2019 - 12:30 to 13:30

    Join the Conway Chair Conversation the 3rd Tuesday of every month. A themed lunch will be served. WebEx available. CNE provided.

  • Jan
    21
    Tue, 01/21/2020 - 12:30 to 13:30

    Join the Conway Chair Conversation the 3rd Tuesday of every month. A themed lunch will be served. WebEx available. CNE provided.

  • Jan
    27
    Mon, 01/27/2020 - 13:00 to 14:00
    The Neuroscience Trainee-Sponsored Seminar Series hosts Katie Drerup, PhD of NICHD. 
  • October 10th, 2019
     
    The National Institutes of Health (NIH) awarded a research team from George Washington, Yale, and Duke Universities $7.8 million to establish a rare disease network for Myasthenia Gravis.

    Part of this funding has been made available to support two RFAs: a Scholar Program targeting clinical fellows, post-doctoral fellows, and junior faculty, a Pilot Program for faculty members. Get full details here
  • October 4th, 2019

     

    The Pilot and Translational Clinical (PTC) Studies module of the CTSI-CN announces the release of the 2020-2021 RFAs.  All high impact research relevant to health and well-being throughout the lifespan is eligible. Support is NOT limited to pediatric research. Letters of Intent are due November 15, 2019

  • September 26th, 2019

    The FDA and CTSI-CN are cosponsoring a Boot Camp for Children's National fellows. Click here to learn more. Click here to express interest. 

  • September 12th, 2019

        

    Eiman Abdulrahman, MD and Susan Keller, MLS invite ALL faculty and staff to attend this new writing program following the book, Essentials of Writing Biomedical Research Papers. The group will meet every other Thursday at Children's National from 1-2 pm. WebEx available. Register here

  • August 27th, 2019

     

    CTSI-CN is your Research Support Center! Learn about all of our tools, resources, and services on September 11 from 12-2 pm in the Research Atrium at Children's National. More details are available here

  • August 19th, 2019

    Did you know CTSI-CN is on Twitter? For learn more faster, follow us at twitter.com/CTSICN

  • July 1st, 2019
    Letters of Intent are due November 1, 2019 for the Clinic and Laboratory Integration Program (CLIP), which provides $200,000 over two years for scientists with faculty appointments. 
  • June 20th, 2019

    This didactic lecture series covers a variety of topics including statistics in medicine, robotics, molecular medicine, mobile health apps, innovation, and clinical competency in clinical trials. These sessions are open to all summer students in CRI, SZIPSI, and Volunteer Services. 2019 Summer Student Lecture Series (pdf) 

  • May 29th, 2019

    Notice of Special Interest (NOSI) from NHLBI on behavioral, biological, psychosocial and/or environmental factors in infancy & earlychildhood (0-24 months) that influence obesity development. Details are available here

  • May 21st, 2019

    The U.S. Department of Health and Human Services (HHS) recently proposed a new rule to support seamless and secure access, exchange, and use of electronic health information (EHI). Comments are due by 11:59 pm on June 3, 2019. More details are available here. Full details and related documents are here

  • May 16th, 2019

    Have your PhD research published in Science magazine, win $30,000 in prize money, and travel to Sweden for the award ceremony. PhDs received in 2017 and 2018 are eligible. Apply by June 15, 2019. 

  • May 8th, 2019


    Check out the latest issue of Women's Health in Focus here. The NIH Office of Research on Women's Health can be found here

  • April 26th, 2019


    The 2019 National Math Festival has talks, performances, and activities for kids of all ages, even the grown-ups. It will be Saturday, May 4 at the Walter E. Washington Convention Center. Get all the details here: nationalmathfestival.org

  • April 25th, 2019


    Unpaywall.org is an open database of more than 25 million scholarly articles harvested from over 50,000 publishers and repositories, making it easy to find, track, and use the information that you need. 

  • April 18th, 2019


    On April 8th, 2019, W@TCH hosted Dee Henderson, Senior PR Specialist & Science Writer, to give a lecture on how to work proactively with public relations to ace that interview, ensure your news release reaches the right reporters at the right time, and you sound and look polished and professional.

Impact

How has the CTSI-CN supported your research?
Tell us about it here.  

Support Pediatric Research

Support care. Fund research. Improve lives. Children’s National takes on some of the most daunting medical research issues to improve children’s lives. Our experts develop therapies, find cures, and improve children's health in our community, across the nation, and around the world. Click here to learn more and offer your support for Pediatric Research at Children's National. Donations contribute to innovative research in a wide range of programs.