Basic Research
Basic research involves scientific exploration that can reveal fundamental mechanisms of biology, disease or behavior. Every stage of the translational research spectrum builds upon and informs basic research. NCATS scientists typically do not conduct basic research; however, insights gained from the Center’s studies along the translational spectrum can inform basic research.
Pre-Clinical Research
Pre-clinical research connects the basic science of disease with human medicine. During this stage, scientists develop model interventions to further understand the basis of a disease or disorder and find ways to treat it. Testing is carried out using cell or animal models of disease; samples of human or animal tissues; or computer-assisted simulations of drug, device or diagnostic interactions within living systems.
Clinical Research
Clinical research includes studies to better understand a disease in humans and relate this knowledge to findings in cell or animal models; testing and refinement of new technologies in people; testing of interventions for safety and effectiveness in those with or without disease; behavioral and observational studies; and outcomes and health services research. The goal of many clinical trials is to obtain data to support regulatory approval for an intervention.
Clinical Implementation
The clinical implementation stage of translation involves the adoption of interventions that have been demonstrated to be useful in a research environment into routine clinical care for the general population. This stage also includes implementation research to evaluate the results of clinical trials and to identify new clinical questions and gaps in care.
Public Health
In this stage of translation, researchers study health outcomes at the population level to determine the effects of diseases and efforts to prevent, diagnose and treat them. Findings help guide scientists working to assess the effects of current interventions and to develop new ones.
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Front

  • September 25th, 2018

    NIH considers extension requests for Early Stage Investigators (ESI) on a case-by-case basis for medical concerns, disability, extended periods of clinical training, natural disasters, and active duty military service. Effective immediately, NIH will approve an ESI extension of one year for childbirth within the ESI period. Learn more about the policy change HERE

  • September 25th, 2018
    The NIH Office of Clinical Research is offering a free, online, self-paced course.  The course runs from October 1, 2018 through June 20, 2019. Click the title for additional details. 
  • September 24th, 2018

    The Writing Institute is designed to help YOU develop the habit of writing. The second Thursday of every month, a talented author from Children's National will describe how they made writing a habit. GW faculty and staff are welcome to attend. WebEx is not available. 

  • September 21st, 2018

    The Board of Visitors is accepting Letters of Intent from Children's National staff. Letters are due by October 1, 2018

  • September 20th, 2018
    Starting next week, George Washington University's Office of Sponsored Projects is offering a fall series of award management trainings from pre- to post-award on a variety of focused topics. Click the title to learn more and register. 
  • September 12th, 2018

    Applications are due September 21 for funded travel to and attendance at the mobilize workshop, Rapid Biomedical Knowledge Base Construction from Text, at Stanford University. The November workshop is free to attend, but space is limited.

  • September 12th, 2018

    The Science of Team Science conference is the annual international forum dedicated to bringing together thought leaders and practitioners from a broad range of disciplines, fields, and professions. Click the title above to learn more, including the abstract submission and registration deadlines. 

  • September 10th, 2018
    Experts from FDA’s Center for Drug Evaluation and Research (CDER), Center for Biologics Evaluation and Research (CBER), Center for Devices and Radiological Health (CDRH), the University of Maryland, and the University of Pennsylvania will provide a deep dive into the scientific background and practical methodology needed when conducting clinical trials.
  • September 4th, 2018
    The purpose of this contest is to find the best ideas in all of CTSA-land for encouraging better team science. Any person associated with a CTSA hub is eligible. Click the title above to learn more. 
  • June 7th, 2018

    Translating Translation "NCATS is unique at NIH in that the name in the Center’s mission — “translation” — has a firmly established meaning that is generally associated with languages, not biomedical research. By contrast, other NIH components are named for widely known medical problems, such as cancer, diabetes and stroke." 

  • June 4th, 2018

    "The modern news release is now directly consumed by the public. Here are some of the best practices gathered by NIH communications offices for writing clear news releases that also inform the public about a scientific finding."

  • June 4th, 2018

    In late April, Dr. Mike Lauer, NIH Deputy Director for Extramural Reserach, wrote about the benefits and drawbacks of using surrogate endpoints in clinical trials. Read his thoughts here...

  • May 23rd, 2018

    May 28th, 2018 is the final day to submit Letters of Intent and CVs for the NIH Lasker Clinical Research Scholars Program. All submissions must be forwarded to the attention of CTSI-CN KL2 Program Lead, Ms. Rachel Smilow at rsmilow@childrensational.org.

  • May 21st, 2018

    Thinking about becoming an Early Career Reviewer (ECR)? By joining the National Institutes of Health Center for Scientific Review's Early Career Reviewer Program you can learn from the experiences of ECRs who have served on NIH Peer Review study sections.

  • May 2nd, 2018

    George Washington University is offering a new online, 3-credit-hour, 30-CME course, Grantsmanship in Clinical and
    Translational Research.

Impact

Has the CTSI-CN has supported your research? Tell us about it here.  

Support Pediatric Research

Support care. Fund research. Improve lives. Children’s National takes on some of the most daunting medical research issues to improve children’s lives. Our experts develop therapies, find cures, and improve children's health in our community, across the nation, and around the world. Click here to learn more and offer your support for Pediatric Research at Children's National. Donations contribute to innovative research in a wide range of programs.