Basic Research
Basic research involves scientific exploration that can reveal fundamental mechanisms of biology, disease or behavior. Every stage of the translational research spectrum builds upon and informs basic research. NCATS scientists typically do not conduct basic research; however, insights gained from the Center’s studies along the translational spectrum can inform basic research.
Pre-Clinical Research
Pre-clinical research connects the basic science of disease with human medicine. During this stage, scientists develop model interventions to further understand the basis of a disease or disorder and find ways to treat it. Testing is carried out using cell or animal models of disease; samples of human or animal tissues; or computer-assisted simulations of drug, device or diagnostic interactions within living systems.
Clinical Research
Clinical research includes studies to better understand a disease in humans and relate this knowledge to findings in cell or animal models; testing and refinement of new technologies in people; testing of interventions for safety and effectiveness in those with or without disease; behavioral and observational studies; and outcomes and health services research. The goal of many clinical trials is to obtain data to support regulatory approval for an intervention.
Clinical Implementation
The clinical implementation stage of translation involves the adoption of interventions that have been demonstrated to be useful in a research environment into routine clinical care for the general population. This stage also includes implementation research to evaluate the results of clinical trials and to identify new clinical questions and gaps in care.
Public Health
In this stage of translation, researchers study health outcomes at the population level to determine the effects of diseases and efforts to prevent, diagnose and treat them. Findings help guide scientists working to assess the effects of current interventions and to develop new ones.
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COVID-19 Response

Please know that you have the full support of the CTSI-CN as we navigate this unprecedented time. As COVID-19 continues to evolve, we are following the lead from Children's National Hospital and George Washington University and adjusting our onsite presence. Though physical offices are temporarily closed, the CTSI-CN remains open for business virtually. This allows us to continue our work with the researchers we currently serve and presents an opportunity to help researchers who have yet to use our services. For questions, contact our CTSI-CN Navigators. To request support, go to SPARC.

  • Apr
    9
    Thu, 04/09/2020 - 15:00 to 16:00

    ResearchMatch is a free participant recruitment and feasibility analysis tool for researchers at participating institutions. The tool is offered to researchers who are conducting research which is health related.

  • Apr
    14
    Tue, 04/14/2020 - 14:00 to 15:00

    Protocol Builder is now at George Washington University! Join BRANY and the CTSI-CN for a free introductory webinar/live demo of this novel protocol writing tool. This session will focus on general Protocol Builder use for GW investigators.

     

  • Apr
    27
    Mon, 04/27/2020 - 13:00 to 14:00

    The Neuroscience Trainee-Sponsored Seminar Series hosts Adam Hantman, PhD of the Howard Hughes Medical Institute. 
  • May
    5
    Tue, 05/05/2020 - 12:30 to 13:30

    Join the Conway Chair Conversation the 1st Tuesday of every month. A themed lunch will be served. WebEx available. CNE provided.

  • May
    14
    Thu, 05/14/2020 - 15:00 to 16:00

    ResearchMatch is a free participant recruitment and feasibility analysis tool for researchers at participating institutions. The tool is offered to researchers who are conducting research which is health related.

  • May
    18
    Mon, 05/18/2020 - 13:00 to 14:00

    The Neuroscience Trainee-Sponsored Seminar Series hosts Peter Basser, PhD of the National Institute of Child Health and Human Development. 
  • Jun
    11
    Thu, 06/11/2020 - 15:00 to 16:00

    ResearchMatch is a free participant recruitment and feasibility analysis tool for researchers at participating institutions. The tool is offered to researchers who are conducting research which is health related.

  • Jul
    9
    Thu, 07/09/2020 - 15:00 to 16:00

    ResearchMatch is a free participant recruitment and feasibility analysis tool for researchers at participating institutions. The tool is offered to researchers who are conducting research which is health related.

  • Aug
    13
    Thu, 08/13/2020 - 15:00 to 16:00

    ResearchMatch is a free participant recruitment and feasibility analysis tool for researchers at participating institutions. The tool is offered to researchers who are conducting research which is health related.

  • Sep
    10
    Thu, 09/10/2020 - 15:00 to 16:00

    ResearchMatch is a free participant recruitment and feasibility analysis tool for researchers at participating institutions. The tool is offered to researchers who are conducting research which is health related.

  • Oct
    8
    Thu, 10/08/2020 - 15:00 to 16:00

    ResearchMatch is a free participant recruitment and feasibility analysis tool for researchers at participating institutions. The tool is offered to researchers who are conducting research which is health related.

  • Nov
    12
    Thu, 11/12/2020 - 15:00 to 16:00

    ResearchMatch is a free participant recruitment and feasibility analysis tool for researchers at participating institutions. The tool is offered to researchers who are conducting research which is health related.

  • Dec
    10
    Thu, 12/10/2020 - 15:00 to 16:00

    ResearchMatch is a free participant recruitment and feasibility analysis tool for researchers at participating institutions. The tool is offered to researchers who are conducting research which is health related.

  • March 26th, 2020

    NCATS and CLIC are partnering resources to facilitate discussions around COVID-19. 

  • March 19th, 2020

    On March 18, 2020, the Food & Drug Administration (FDA) issued

  • March 12th, 2020

    Organization: U.S. Food and Drug Administration (FDA)

    Reference Code: FDA-CDER-2020-0521

    How to Apply: A complete application consists of:      

  • February 26th, 2020

    CTSI-CN announces the release of the 2020-21 Translational Team Science Awards (TTSAs). TTSAs aim to promote creative, multidisciplinary team-based research focused on complex or challenging biomedical research questions. Teams may be formed from any combination of academic labs, clinical partners, industry or foundations. The project period is 12 months long with no extensions. Applications are due April 23, 2020. Visit CTSI-CN Funding for details and to download the RFA. 

  • February 26th, 2020

    Harnessing the patient’s own immune system to fight cancer, rather than traditional chemotherapy drugs

  • December 9th, 2019

    NIH recently announced the opening of registration for the 2019-2020 Introduction to the Principles and Practice of Clinical Research (IPPCR) series. This free, online course is a thorough and comprehensive introduction to clinical research.

  • October 10th, 2019
     
    The National Institutes of Health (NIH) awarded a research team from George Washington, Yale, and Duke Universities $7.8 million to establish a rare disease network for Myasthenia Gravis.

    Part of this funding has been made available to support two RFAs: a Scholar Program targeting clinical fellows, post-doctoral fellows, and junior faculty, a Pilot Program for faculty members. Get full details here
  • October 4th, 2019

     

    CTSI-CN announces the release of the 2020-2021 Pilot RFAs.  All high impact research relevant to health and well-being throughout the lifespan is eligible. Support is NOT limited to pediatric research. Letters of Intent are due November 15, 2019. Visit CTSI-CN Funding for details and to download the RFAs. 

  • September 26th, 2019

    The FDA and CTSI-CN are cosponsoring a Boot Camp for Children's National fellows. Click here to learn more. Click here to express interest. 

  • September 12th, 2019

        

    Eiman Abdulrahman, MD and Susan Keller, MLS invite ALL faculty and staff to attend this new writing program following the book, Essentials of Writing Biomedical Research Papers. The group will meet every other Thursday at Children's National from 1-2 pm. WebEx available. Register here

  • August 27th, 2019

     

    CTSI-CN is your Research Support Center! Learn about all of our tools, resources, and services on September 11 from 12-2 pm in the Research Atrium at Children's National. More details are available here

  • August 19th, 2019

    Did you know CTSI-CN is on Twitter? For learn more faster, follow us at twitter.com/CTSICN

  • July 1st, 2019
    Letters of Intent are due November 1, 2019 for the Clinic and Laboratory Integration Program (CLIP), which provides $200,000 over two years for scientists with faculty appointments. 
  • June 20th, 2019

    This didactic lecture series covers a variety of topics including statistics in medicine, robotics, molecular medicine, mobile health apps, innovation, and clinical competency in clinical trials. These sessions are open to all summer students in CRI, SZIPSI, and Volunteer Services. 2019 Summer Student Lecture Series (pdf) 

  • May 29th, 2019

    Notice of Special Interest (NOSI) from NHLBI on behavioral, biological, psychosocial and/or environmental factors in infancy & earlychildhood (0-24 months) that influence obesity development. Details are available here

Support Pediatric Research

Support care. Fund research. Improve lives. Children’s National Hospital takes on some of the most daunting medical research issues to improve children’s lives. Our experts develop therapies, find cures, and improve children's health in our community, across the nation, and around the world. Click here to learn more and offer your support for Pediatric Research at Children's National. Donations contribute to innovative research in a wide range of programs.