Basic Research
Basic research involves scientific exploration that can reveal fundamental mechanisms of biology, disease or behavior. Every stage of the translational research spectrum builds upon and informs basic research. NCATS scientists typically do not conduct basic research; however, insights gained from the Center’s studies along the translational spectrum can inform basic research.
Pre-Clinical Research
Pre-clinical research connects the basic science of disease with human medicine. During this stage, scientists develop model interventions to further understand the basis of a disease or disorder and find ways to treat it. Testing is carried out using cell or animal models of disease; samples of human or animal tissues; or computer-assisted simulations of drug, device or diagnostic interactions within living systems.
Clinical Research
Clinical research includes studies to better understand a disease in humans and relate this knowledge to findings in cell or animal models; testing and refinement of new technologies in people; testing of interventions for safety and effectiveness in those with or without disease; behavioral and observational studies; and outcomes and health services research. The goal of many clinical trials is to obtain data to support regulatory approval for an intervention.
Clinical Implementation
The clinical implementation stage of translation involves the adoption of interventions that have been demonstrated to be useful in a research environment into routine clinical care for the general population. This stage also includes implementation research to evaluate the results of clinical trials and to identify new clinical questions and gaps in care.
Public Health
In this stage of translation, researchers study health outcomes at the population level to determine the effects of diseases and efforts to prevent, diagnose and treat them. Findings help guide scientists working to assess the effects of current interventions and to develop new ones.
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Front

  • Jun
    19
    Tue, 06/19/2018 - 12:00 to 13:00

    Learning Objectives: 
    1. Know what dissemination, implementation science, and dissemination science are; 2. Understand the features
    of Dissemination and Implementation (D&I) research studies and what makes D&I research studies different from usual
    clinical trials; and 3. Be able to identify funding sources for D&I research. 

  • Jun
    28
    Thu, 06/28/2018 - 08:00 to 09:00

    Women at Children's Hospital (WATCH)
    Grand Rounds and Workshop 

  • Jul
    10
    Tue, 07/10/2018 - 11:00 to 13:00

    The CTSI-CN is pleased to continue to offer Research Electronic Data Capture (REDCap) training to the Child-
    ren's National and GW research communities. Please join us for REDCap 101, an intensive, hands-on Database
    Design course!

  • June 7th, 2018

    Translating Translation "NCATS is unique at NIH in that the name in the Center’s mission — “translation” — has a firmly
    established meaning that is generally associated with languages, not biomedical research. By contrast, other NIH
    components are named for widely known medical problems, such as cancer, diabetes and stroke." 

  • June 4th, 2018

    "The modern news release is now directly consumed by the public. Here are some of the best practices gathered by NIH
    communications offices for writing clear news releases that also inform the public about a scientific finding."

  • June 4th, 2018

    In late April, Dr. Mike Lauer, NIH Deputy Director for Extramural Reserach, wrote about the benefits and drawbacks
    of using surrogate endpoints in clinical trials. Read his thoughts here...

Impact

Has the CTSI-CN has supported your research? Tell us about it here.  

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