Basic Research
Basic research involves scientific exploration that can reveal fundamental mechanisms of biology, disease or behavior. Every stage of the translational research spectrum builds upon and informs basic research. NCATS scientists typically do not conduct basic research; however, insights gained from the Center’s studies along the translational spectrum can inform basic research.
Pre-Clinical Research
Pre-clinical research connects the basic science of disease with human medicine. During this stage, scientists develop model interventions to further understand the basis of a disease or disorder and find ways to treat it. Testing is carried out using cell or animal models of disease; samples of human or animal tissues; or computer-assisted simulations of drug, device or diagnostic interactions within living systems.
Clinical Research
Clinical research includes studies to better understand a disease in humans and relate this knowledge to findings in cell or animal models; testing and refinement of new technologies in people; testing of interventions for safety and effectiveness in those with or without disease; behavioral and observational studies; and outcomes and health services research. The goal of many clinical trials is to obtain data to support regulatory approval for an intervention.
Clinical Implementation
The clinical implementation stage of translation involves the adoption of interventions that have been demonstrated to be useful in a research environment into routine clinical care for the general population. This stage also includes implementation research to evaluate the results of clinical trials and to identify new clinical questions and gaps in care.
Public Health
In this stage of translation, researchers study health outcomes at the population level to determine the effects of diseases and efforts to prevent, diagnose and treat them. Findings help guide scientists working to assess the effects of current interventions and to develop new ones.
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CTSI-CN Leadership Statement

The CTSI-CN offers our heartfelt condolences to the family of George Floyd and all victims of racism and prejudice. Our mission is to advance the health and well-being of our community, including its minority and underserved populations.

We will listen, we will learn, and we will think creatively about how research initiatives can help move us towards solutions.

Most importantly, we will not turn away. We will be present to support our researchers and our communities through this difficult time in our city and our nation.

  • Jul
    Tue, 07/13/2021 - 12:00 to 13:00

    The Institute for Advanced Clinical Trials for Children's and the Best Practices, Education & Tools (BET) Committee present the 2021 Educational Webinar Series on July 13 at noon, "Electronic Informed Consent (eConsent)"

  • June 8th, 2021

    Are you interested in translational science? Are you looking to further develop your career and network with peers? Join the Center for Leading Innovation and Collaboration (CLIC) Career Development Community!

  • June 8th, 2021

    Thank you for attending this year's 4th Annual Children's National - NIAID Symposium virtually. Your engagement contributed to the success of the symposium!

  • May 6th, 2021

    We are excited to host you at the 4th Annual Children's National - NIAID SymposiumThis annual symposium celebrates the partnership between Children’s National Hospital (CNH) and the National Institute of Allergy and Infectious Diseases (NIAID). Established in 2017, the CNH-NIAID partnership focuses on advancing the health of children with allergic, immunologic, and infectious diseases through collaborative research and education.

  • April 21st, 2021

    The Johns Hopkins University-Tufts Medical Center Trial Innovation Center (JHU-Tufts TIC) is looking for investigators who are interested in pursuing innovative clinical trial designs to participate in its annual Design Lab workshops.


  • April 20th, 2021

    The National Institutes of Health’s new ACTIV-6 trial will use #DrugRepurposing to test several existing drugs to determine whether they provide safe, effective symptom relief for mild to moderate #COVID19 symptoms at home.

  • April 7th, 2021

    April 12-16, 2021: The Global Health Initiative at Children's National Hospital is excited to announce the Spring 2021 Schedule! Each session is designed to meet specific objectives of the Global Health Curriculum.

  • March 25th, 2021

    Join leaders in improving children's health. Train to be the next generation of multidisciplinary collaborators.

  • February 19th, 2021

    Heart2HEART Healing, Empowering and Restorative Therapy is recruiting pregnant women who receive a confirmed fetal CHD diagnosis that will require open heart surgery after their baby is born. Our research aims to understand these women’s unique experiences and mental health concerns and will provide information about the impact of prenatal CBT on future moms’ psychological anxiety, depression and stress.

  • February 10th, 2021

    More than 40 CTSA Program hubs have helped build the National COVID Cohort Collaborative (N3C) Data Enclave. This powerful tool provides researchers with information on #COVID19 clinical data gathered from across the United States.

  • February 9th, 2021

    Congratulations to Dr. Bushardt and DR. Gomberg-Maitlant in their new CTSI-CN roles!

  • December 2nd, 2020

    Meet Alison K. Hall, PhD, the Co-Director of the KL2 Career Development Program at CTSI-CN. CTSI-CN Conversations is a video series featuring the faculty and staff behind the program.

  • November 25th, 2020

    The Office for the Protection of Human Subjects at Children's National Hospital and the CTSI-CN REDCap team are pleased to announce that Phase 2 of e-consent using the REDCap platform is now live.

  • November 24th, 2020

    A 3-hour credit hour online course from 1/11/21 - 4/26/21 for MDs, Research Scientists, Faculty & PhDs. This course is offered by the GW School of Medicine and Health Sciences.

  • October 12th, 2020

    Leading experts came together at the 3rd Annual Children’s National – NIAID Virtual Symposium to highlight the incredible work being done to fight the COVID-19 pandemic globally, with a strong emphasis on the health of the pediatric population.

  • September 18th, 2020

    Join the N3C initiative and help save lives by collaborating to reduce immediate and long-term impacts of COVID-19.

Established in 2017, the CNH-NIAID partnership focuses on advancing the health of children with allergic, immunologic, and infectious diseases through collaborative research and education. This year, the virtual Symposium featured current research on COVID-19 and multisystem inflammatory syndrome in children (MIS-C), & the intersectionality of COVID-19, allergy, and immunology on the pediatric population. Learn more about the agenda & speakers at The recorded sessions are also now available.