The Clinical and Translational Science Institute at Children's National (CTSI-CN) is proud to support Children's National Health System and The George Washington University research faculty and staff by providing a variety of supportive resources and tools.
Cohort Discovery & Feasibility
Please note: Currently the following resources are only available for study feasibility and cohort discovery. They are not yet available for recruitment purposes. approval of an "honest broker" process to enable recruitment is pending.
i2b2 / ACT Network (SHRINE)
i2b2, or Informatics for Integrating Biology & the Bedside, is an NIH-funded scalable informatics framework that links data warehouses across partner institutions. Locally, i2b2 facilitates exploration and query of the clinical data within PowerChart that has been de-identified and aggregated. In doing so, i2b2 helps with study feasibility and cohort discovery by allowing a researcher to query various inclusion/exclusion criteria, as well as ascertain the potential for recruitment.
The ACT Network (SHRINE), is integrated into the i2b2 platform and supports multi-site research by enabling study feasibility and cohort discovery at over 30 partner institutions.
At Children’s National Health System both i2b2 and the ACT Network are support by CTSI-CN's INformatic System for Integrating Genomics, Health and Translational Sciences (INSIGHTS) program.
To learn more about i2b2 and the ACT Network (SHRINE) please visit: i2b2 / ACT Network (SHRINE)
Please Note: As both tools currently only allow access to de-identified, aggregate data no IRB approval is required.
TriNetX is a dynamic, data driven platform that leverages the i2b2 data warehouse and Cerner PowerChart (EHR). Employing a clean and easily navigable user interface, a research easily generate a query to perform study feasibility and cohort discovery. Additionally, TriNetX has the ability to perform analysis of the identified cohort and “estimated rate of arrival” projections. TriNetX is a valuable resource for accelerating the conduct of both investigator-initiated and industry research.
As of March 2018, with the addition of "TriNetX Research" TriNetX now offers the ability to collaborate with Health Care Organizations (HCO) from around the world to conduct real world evidence (RWE) research.
Please Note: As TriNetX currently only allows access to de-identified, aggregate data, no IRB approval is required.
To learn more about TriNetX please visit: TriNetX
PowerTrials Prescreening is a Cerner-developed, HIPAA compliant prescreening application that enables a Researcher to search the electronic health record (EHR) for potential research participants using pre-established inclusion and/or exclusion criteria. This tool allows for the discovery of potentially eligible patients both at the point of care, and those admitted within a recent timeframe.
To learn more about PowerTrials Prescreening please visit: PowerTrials Prescreening
Recruitment & Retention Report
In 2017, the CTSI-CN generated and distributed a comprehensive survey to all Children's National and The George Washington research faculty and staff to evaluate and assess factors related to the recruitment and retention (R&R) experiences and the need for R&R tools.
To learn more, please see: CTSI-CN LRIC Recruitment and Retention Survey Results
Recruitment & Retention Strategy
The CTSI-CN's Liaison to Recruitment Innovation Centers module has conducted an extensive canvas and review of freely available participant recruitment and retention tools, guides, templates, and other resources. In an effort to build awareness and to support the research community at both Children's National Health System and The George Washington University, we routinely post vetted resources in this section of our website.
The CTSA Trial Innovation Network (TIN) Recruitment and Retention Toolbox
The CTSA Trial Innovation Network (TIN) Recruitment and Retention Toolbox includes links to materials designed by or for other CTSA program staff and institutions. The site covers a variety of resources and information and includes evidence-based or evidence-informed recruitment and retention best practices.
To learn more about the CTSA Trial Innovation Network (TIN) Recruitment and Retention Toolbox please visit: https://trialinnovationnetwork.org/recruitment-retention-toolkit/
The Clinical Trials Transformation Initiative: Recruitment
The Clinical Trials Transformation Initiative: Recruitment Project provides an overview of the Recruitment and Retention process and includes the CTTI Recommendations on Efficient and Effective Clinical Trial Recruitment Planning among other documents.
To learn more about the Clinical Trials Transformation Initiative: Recruitment Project please visit: https://www.ctti-clinicaltrials.org/projects/recruitment
The National Institute of Mental Health at NIH: Points to Consider about Recruitment and Retention while Preparing a Clinical Research Study
The National Institute of Mental Health at NIH: Points to Consider about Recruitment and Retention while Preparing a Clinical Research Study webpage clearly lays out some of the common issues that can impact the recruitment and retention of clinical research participants and, where applicable, offers suggestions on how to address them.
To learn more about the National Institute of Mental Health at NIH: Points to Consider about Recruitment and Retention while Preparing a Clinical Research Study webpage please visit: https://www.nimh.nih.gov/funding/grant-writing-and-application-process/points-to-consider-about-recruitment-and-retention-while-preparing-a-clinical-research-study.shtml/
ResearchMatch (for Researchers)
ResearchMatch is a NIH-funded, national registry that brings together researchers and 125,000+ volunteers who are interested in learning more about research studies. Used nationally by over 5,700 researchers this novel platform has been helpful in recruiting research participants across many research areas, and has been particularly useful for research involving rare disease, surveys, and healthy volunteers.
To learn more about ResearchMatch (for Researchers) please visit: ResearchMatch (for Researchers)
Request Support (SPARC Request)
SPARC Request (Services, Pricing, & Application for Research Centers) is a web-based research transaction management system that was created at the Medical University of South Carolina (MUSC). SPARC Request provides a central portal for researchers and their study teams to browse for research services and resources as well as submit service and pricing requests.
SPARC Request features include:
Order services from various CTSI-CN modules/cores
Create budgets for studies/projects
Manage active studies/projects within the user Dashboard
Track research activity for services provided by CTSI-CN Cores
Fulfill service requests in real-time
Communicate directly with your service providers
Generate various reports for study teams
To learn more about SPARCRequest please visit: Request Support (SPARC Request)