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History & Overview

In July 2010, Children’s National Hospital was awarded the prestigious Clinical and Translational Science Award (CTSA) grant, from the National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS), to establish the Clinical and Translational Science Institute at Children’s National (CTSI-CN). The CTSI-CN was organized as a collaboration between Children’s National and its academic partner, The George Washington University (GW). In July 2016, we were awarded our second 5-year grant with the continued strategic mission to promote high-quality research, efficient translation of discoveries to human application, effective implementation into clinical practice, and improved quality of life for children and their families.

The CTSI-CN provides highly integrated, cost-effective, and investigator-focused resources in five key strategic areas that have been emphasized by NCATS to support effective clinical and translational research (CTR). Operationally, the CTSI-CN is organized in a set of modules that provide: 1) programs for workforce development; 2) approaches to build collaborative teams and engage community stakeholders; 3) integration of diverse, complementary expertise in study team development; 4) the development/adaptation of methodologies for effective trial design; and 5) the implementation of a progressive and technologically innovative informatics platform that will facilitate the integration of health care systems and the research enterprise.

The Aims of our NIH CTSA Grant:

Aim 1: Develop a new generation of diverse, high quality, child health-focused CTR investigators through innovative educational, training, and mentoring programs (WORKFORCE DEVELOPMENT).

Aim 2: Create innovative approaches and technologies to catalyze CTR, particularly in child-health, through novel cross-disciplinary collaborations that engage multiple stakeholder communities (COLLABORATION AND ENGAGEMENT).

Aim 3: Foster multi-disciplinary teams capable of conducting child-health CTR across the translational spectrum to address health disparities, fetal/maternal medicine, and rare genetic diseases (INTEGRATION).

Aim 4: Catalyze the development, evaluation, and dissemination of novel methods to enhance CTR, with a particular emphasis on the child-health CTR spectrum from conception to adulthood (METHODS AND PROCESSES).

Aim 5: Advance child-health CTR through a comprehensive, integrated information ecosystem, with user-friendly training in informatics methods and tools (INFORMATICS).