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FOOD ALLERGY PROGRAM

PROTOCOL TITLE: NATURAL HISTORY AND MECHANISTIC INVESTIGATION OF ATOPIC DISEASE OF CHILDHOOD

The prevalence of atopic and allergic diseases has increased both in developed and developing countries in recent decades. Atopic diseases typically manifest in early childhood, progress through the first decade of life through what has become known as the ‘atopic march’ and then often persist throughout one’s lifetime. This study will investigate the natural history of a/the peanut allergy in a cohort of food-allergic and food-sensitized infants and determine whether allergy and sensitization is attributable to differences in regulatory T and B cell frequency/function compared with non-allergic, age-matched controls.

Children's National

NIAID